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AI Customer Support Software That Integrates with Twilio (2026)

Twilio provides the programmable voice and messaging layer many custom support stacks are built on, including Twilio Flex contact centers. The tools below integrate with it, whether they run voice AI over Twilio's telephony, send and receive SMS through it, or deploy into Flex. If your stack is already Twilio-based, these fit without re-architecting.

How this list works: every tool below lists Twilio among its published integrations. It is the full set in the directory, not a hand-picked shortlist; integration depth varies, so confirm the specifics on the vendor's site before you commit.

15 tools that integrate with Twilio

1. #1

   Ada

   Ada’s AI Agent automates seamless, delightful customer service across the channels your customers prefer.

   PricingPaid · CustomWorks withZendeskSalesforceServiceNowShopify+2 more

   Full Ada listing →  ·  Ada alternatives →

2. #2

   Cognigy

   Support your customers and agents with Cognigy.AI, powered by Generative AI on voice and chat

   PricingPaid · CustomWorks withGenesysAmazon ConnectAvaya8x8+4 more

   Full Cognigy listing →  ·  Cognigy alternatives →

3. #3

   Gemini Enterprise for Customer Experience

   Google Cloud's AI customer service stack with buildable voice and chat agents, real-time agent assist, and metered per-session pricing.

   PricingPaid · $0.50/sessionWorks withUJETGenesysCiscoFive9+4 more

   Full Gemini Enterprise for Customer Experience listing →  ·  Gemini Enterprise for Customer Experience alternatives →

4. #4

   Gladly Sidekick

   Gladly's AI-powered Customer Service Platform centers on people, not tickets, leading to delightful experiences and revenue growth while cutting costs.

   PricingPaid · ~$180/seat/moWorks withShopifySalesforceZendeskTwilio+2 more

   Full Gladly Sidekick listing →  ·  Gladly Sidekick alternatives →

5. #5

   Kore.ai

   Enterprise agentic AI platform for building customer and employee-facing assistants across chat and voice.

   PricingPaid · CustomWorks withGenesysAmazon ConnectSalesforceServiceNow+2 more

   Full Kore.ai listing →  ·  Kore.ai alternatives →

6. #6

   Kustomer

   CRM-based customer service platform with AI agents that see the full customer, not just the ticket.

   PricingPaid · CustomWorks withShopifySlackSalesforceWhatsApp+2 more

   Full Kustomer listing →  ·  Kustomer alternatives →

7. #7

   Lorikeet

   AI concierge for high-stakes support in fintech, healthcare, and marketplaces that follows your procedures exactly.

   PricingPer resolution · $1,500/mo + $0.95/resolutionWorks withZendeskIntercomSalesforceHubSpot+3 more

   Full Lorikeet listing →  ·  Lorikeet alternatives →

8. #8

   Loris

   Conversation intelligence platform, now part of Contentsquare, that analyzes every support interaction for intent, sentiment, automated QA, and AI agent performance.

   PricingPaid · CustomWorks withZendeskSalesforceKustomerGladly+2 more

   Full Loris listing →  ·  Loris alternatives →

9. #9

   Parloa

   AI Agent Management Platform focused on natural, human-sounding phone automation for contact centers.

   PricingPaid · CustomWorks withGenesysAmazon ConnectTwilioSalesforce+2 more

   Full Parloa listing →  ·  Parloa alternatives →

10. #10

    Replicant

    Enterprise voice AI that resolves routine contact center calls end to end, with chat and SMS alongside human handoff.

    PricingPaid · CustomWorks withFive9GenesysAmazon ConnectNICE+4 more

    Full Replicant listing →  ·  Replicant alternatives →

11. #11

    Retell AI

    Self-serve platform for building, testing, and monitoring AI phone agents, priced per minute with published component costs.

    PricingPaid · $0.07/minWorks withTwilioVonageTelnyxCal.com+5 more

    Full Retell AI listing →  ·  Retell AI alternatives →

12. #12

    Sierra AI

    AI agent mirrors the nuances of human communication, ensuring seamless and organic customer service interactions while improving customer satisfaction.

    PricingPer resolution · CustomWorks withSalesforceZendeskShopifyTwilio+2 more

    Full Sierra AI listing →  ·  Sierra AI alternatives →

13. #13

    Vapi

    Developer-first API platform for building voice AI agents, orchestrating your choice of speech, LLM, and telephony providers.

    PricingPaid · $0.05/min + provider costsWorks withTwilioVonageTelnyxDeepgram+4 more

    Full Vapi listing →  ·  Vapi alternatives →

14. #14

    Voiceflow

    Collaborative visual platform where teams design, test, and deploy AI chat and voice agents across support channels.

    PricingFreemium · Free; $60/moWorks withZendeskSalesforceTwilioHubSpot+4 more

    Full Voiceflow listing →  ·  Voiceflow alternatives →

15. #15

    Zoho Desk

    Affordable omnichannel help desk with Zia AI for replies, sentiment, and triage, a free plan, and published per-agent pricing.

    PricingFreemium · Free; $7/agent/moWorks withZoho CRMSlackMicrosoft TeamsJira+4 more

    Full Zoho Desk listing →  ·  Zoho Desk alternatives →

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